The relation of bone mineral density with the serum levels of 25 hydroxy-vitamin D in premenopausal and postmenopausal individuals: vitamin D and bone health

Abstract

The frequency of osteoporosis increases by aging. Although the role of vitamin D on bone metabolism is well-known, the results of the trials investigating the relation of vitamin D with the severity of osteoporosis and osteopenia are contradictory. Our aim is to analyze the relation of the serum level of vitamin D with densitometric T and Z scores in pre- and postmenopausal women. A total of 267 participants that are composed of 86 healthy (41 premenopausal, 45 postmenopausal), 90 osteopenic (40 premenopausal, 50 postmenopausal), 91 osteoporotic (35 premenopausal, 56 postmenopausal) individuals were included in the study. Patients under the age of eighteen and over eighty years, as well as those with medical data of additional comorbidities (congestive heart failure, hepatic insufficiency, thyroid disease and chronic kidney disease, primary and secondary hyperparathyroidism) were excluded from the study. Vitamin D, calcium, phosphorus, parathormone, alkaline phosphatase levels were recorded. Participants underwent to bone densitometry examination in Bagcilar Education and Research Hospital. Our study was conducted on women and they were divided into groups as osteoporotic, osteopenic and healthy individuals, and grouped as premenopausal and postmenopausal among themselves. The mean vitamin D level of postmenopausal healthy group was significantly higher than that of premenopausal healthy group. Premenopausal patients with osteoporosis had higher mean ALP levels than premenopausal osteopenic group. We failed to determine an association between vitamin D level and T and Z scores. Administration of vitamin D replacement is excessively common among healthy postmenopausal women, independent from bone densitometry examination. Vitamin D level may not always reflect the exact status of bone densitometry.