Evaluating Complete Blood Count Parameters in Early-Stage Mycosis Fungoides Patients

Abstract

Mycosis Fungoides (MF) is the most common form of primary Cutaneous T cell lymphoma. The disease courses with a slow progression, it progresses into plaque and tumor stage following patch stage. Complete blood cell count is the most frequently used blood test providing basic hematological counts. It is known that the rise in blood cells and the elevation of their rates are related to inflammation and increase in thrombotic risk. We aimed to evaluate the condition of inflammatory and thrombotic markers in early-stage MF patients by comparing complete blood counts and CRP measurements of early-stage MF patients to a healthy control group. The research is a retrospective study. Between 2007 and 2017, 45 patients diagnosed with early stage
MF in our clinic and 45 healthy individuals as a control group were included in the study. Complete blood count parameters and CRP values of the patient and control groups were recorded. In addition, NLR, LMR, PLR, ELR and ENR ratios were calculated. Statistically, p <0.05 was considered significant. Neutrophil (p=0.001), neutrophil-lymphocyte ratio (NLR) (p=0.040), platelet (p=0.021), platecrit (p=0.026), platelet distribution width (PDW) (p=0.009) and CRP (p=0.026) values were detected as significantly high in MF patients compared to the control group. No statistically significant difference was found between both groups in other parameters. Neutrophil, NLR, and CRP markers may be guide the assessment of systemic inflammation in earlystage MF patients. Furthermore, platelet, platecrit and PDW values may be used for determining inflammation and thrombotic risk in MF patients. As a result, the complete blood count parameters may be used as simple, useful, and cost-effective biomarkers for determining the inflammation and thrombotic risk in cancer.