T Cell Immune Profile and Related Cytokines in Gestational Diabetes

Abstract

estational diabetes mellitus (GDM) is a pregnancy complexity and characterized by a proinflammatory immune system response and systemic inflammation with insulin resistance . Because physiological alterations during normal pregnancy are characterized by a live immune response and insulin resistance, it may be owing to improper adaptation of the maternal immune system of GDM. For this reason, studies have focused on investigating the response of T helper cells, in either normal and complex pregnancy. Many of the current studies have investigated relevant alterations in the level of cytokines in the circulation that reflect T helper cell I (Th1) and Th cell 2 (Th2). It is also suggested that different T-cell subsets play a status in regulating the immune response in pregnancy complexities. In particular, these different T cell subsets play a status in various pregnancy complexities. This review provides links among gestational diabetes and T cell subsets in the light of guidelines and literature.