The importance of serum bone alkaline phosphatase in Metabolic Syndrome

Abstract

Purpose: Serum alkaline phosphatase plays a role in vascular calcification. It is found in various tissues, whereas bone-spesific alkaline phosphatase (BAP) more specifically reflects mineral metabolism. The relationship of BAP with metabolic syndrome (MetS) is largely unknown. The aim of our study was to determine the optimal cut off level for BAP assess whether BAP could represent a novel, sensitive marker of bone mineral disease (BMD) in MetS patients.
Methods: 80 MetS patients (57 female and 23 male) and 50 healty individuals (33 female,17 male) were included in this study. BAP levels were measured using on Ostease Kit (Beckman Coulter , California, USA).
Results: Weight, BMI, waist circumference , hypertension, family history, blood pressure were significant higher in MetS group compared to the control group (p=0.0001 for all). HDL, fasting blood glucose ,TG, Insuline, HOMA-IR and BAP were significant higher in patients than control group (p=0.001, p=0.0001 respectively for all) The Receiver Operating Characteristics (ROC) analysis is used to measure the performance of BAP,Insuline and HOMA-IR in detecting bone mineral diseae in metabolıc syndrome .The cut off value off BAP was ≤ 15.1 μg/L. Area under the ROC curve was 0.839 (%95 CI ; 0.764-0.890, SE;0.038) ( sensitivity; 83.75, spesifity; 76, PPV,84.4, NPV,74.5, +LR,3.49 ).
Conclusions: BAP may be a clinically useful bone formation marker to predict the BMD reduction in MetS patients.Further investigations with larger patient groups are required to confirm our results.